In a dramatic scene inspired by Ovid, this fresco panel on the vault of the Loggia of Galatea in the Villa Farnesina, commissioned by the Sienese banker Agostino Chigi, features Perseus, Medusa, and Andromeda as its main figures. Perseus is shown at the moment of beheading Medusa, his sword raised as her serpent-entwined head is about to be severed. Around them, the petrified victims of her gaze stand frozen in rigid postures, contrasting with the movement of the central action. Pegasus, the winged horse said by Ovid to have emerged from Medusa’s blood, rises from the horizon, adding to the sense of motion and transformation within the composition. Andromeda, traditionally depicted near Perseus and Pegasus in celestial representations, is reimagined as a winged Fame. She floats above the scene, playing a trumpet to fill the air with triumphant music. Her billowing drapery and outstretched form contribute to the illusion of weightlessness, reinforcing the sense of depth within the fresco. The placement of figures and the treatment of light and perspective demonstrate Peruzzi’s command of illusionistic painting, making the architectural space appear to expand beyond its physical boundaries. Peruzzi not only painted the vault of the loggia and incorporated geometric frameworks that aligned with the surrounding architecture, but he also designed the villa itself. His ability to unify painting and architecture ensured that the frescoes did not function as isolated decorations but as integral elements of the space. Through this approach, he created a setting where structure and imagery were in dialogue, reinforcing the overall harmony of the Villa Farnesina.